Read more from the “Historic, hopeful moment arrives as COVID-19 vaccinations begin on Medical Campus” article by School of Medicine news release.
Author: philips.j.a
Perspectives on pathogen biosurveillance
Jennifer A. Philips, MD, PhD, associate professor of medicine and co-director of the Division of Infectious Diseases at Washington University School of Medicine in St. Louis, and Gideon Erkenswick, PhD, postdoctoral research associate in Philips’ lab and President of Field Projects International, contribute a Science perspective on improving global wildlife disease surveillance through a decentralized […]
Inhibition of fatty acid oxidation promotes Mtb control
M. tuberculosis (Mtb) is the leading infectious disease killer worldwide. We discovered that intracellular Mtb fails to grow in macrophages in which fatty acid β-oxidation (FAO) is blocked. Macrophages treated with FAO inhibitors rapidly generate a burst of mitochondria-derived reactive oxygen species, which promotes NADPH oxidase recruitment and autophagy to limit the growth of Mtb. […]