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Matta SK, Kohio HP, Chandra P, Brown A, Doench JG, Philips, JA, Ding S, Sibley LD. Genome-wide targeted CRISPR screens identify RNF213 as a mediator of interferon-gamma-dependent pathogen restriction in human cells, Proc. Natl. Acad. Sci ., 2024; 121: e2315865120; PMID: 38147552.
Bobba S, Akter S, Das S, Mittal E, Mathema B, Philips JA, Khader S. A protective role for type I interferon signaling following infection with Mycobacterium tuberculosis carrying the rifampicin drug resistance-conferring RpoB mutation H445Y “, PLoS Pathogens , 2024: 1012137.
Roth, AT, Philips JA, Chandra P. The role of cholesterol and its oxidation products in tuberculosis pathogenesis, Immunometabolism , 2024: e00042. PMID: 38693938
Andrews JT, Zhang Z, Prasad GVR, Huey F, Nazarova EV, Wang J, Ranaraja A, Weinkopff T, Li LX, Mu S, Birrer MJ, Huang SCC, Zhang N, Arguello RJ, Philips JA, Mattila JT, Huang L. Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis . Mucosal Immunol. , 2024. PMID: 38844208.
Mittal E, Prasad GVR, Upadhyay S, Olive A, Yang G, Sassetti CM, Philips JA. Mycobacterium tuberculosis virulence lipid PDIM inhibits autophagy in mice, Nat. Microbiol . , 2024. PMID: 39242815.
Chandra P, Philips JA. USP8 Promotes Intracellular Infection by Enhancing ESCRT-mediated Membrane Repair, Limiting Xenophagy, and Reducing Oxidative Stress, Autophagy , 2024. PMID: 39178916.
Mittal E, Roth AT, Seth A, Singamaneni S, Beatty W, Philips JA. Single cell preparations of Mycobacterium tuberculosis damage the mycobacterial envelope and disrupt macrophage interactions, eLife , 2023: 12: e85416. PMID: 36852737.
Grigsby SJ, Prasad GVR, Mittal E, Wallach JB, Hsu FF, Schnappinger D, Philips, JA. CpsA mediates infection of recruited lung myeloid cells by Mycobacterium tuberculosis , Cell Reports , 2023: PMID: 38127624.
Seth A, Liu Y, Gupta R, Wang Z, Mittal E, Kolla S, Rathi P, Gupta P, Parikh B, Genin G, Gandra S, Storch G, Philips, JA, George I, Singamaneni S. Plasmon-enhanced Digital Fluoroimmunoassay for Sub-femtomolar Detection of Protein Biomarkers, Nano Letters , 2023: PMID: 38146928.
Seth A, Mittal E, Luan J, Kolla S, Mazer MB, Joshi H, Gupta R, Rathi P, Wang Z, Morrissey JJ, Ernst JD, Portal-Celhay C, Morley SC, Philips JA, Singamaneni S. High-resolution imaging of protein secretion at the single-cell level using plasmon-enhanced FluoroDOT assay. Cell Rep Methods. 2022 Aug 22;2(8):100267. doi: 10.1016/j.crmeth.2022.100267. eCollection 2022 Aug 22. PubMed PMID: 36046626; PubMed Central PMCID: PMC9421537.
Chandra P, Grigsby SJ, Philips JA. Immune evasion and provocation by Mycobacterium tuberculosis. Nat Rev Microbiol. 2022 Jul 25;. doi: 10.1038/s41579-022-00763-4. [Epub ahead of print] Review. PubMed PMID: 35879556; PubMed Central PMCID: PMC9310001.
Chandra P, Coullon H, Agarwal M, Goss CW, Philips JA. Macrophage global metabolomics identifies cholestenone as host/pathogen cometabolite present in human Mycobacterium tuberculosis infection. J Clin Invest. 2022 Feb 1;132(3). doi: 10.1172/JCI152509. PubMed PMID: 35104812; PubMed Central PMCID: PMC8803325.
Inomata M, Xu S, Chandra P, Meydani SN, Takemura G, Philips JA, Leong JM. Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33561-33569. doi: 10.1073/pnas.2015368117. Epub 2020 Dec 21. PubMed PMID: 33376222; PubMed Central PMCID: PMC7776987.
Miner JJ, Platt DJ, Ghaznavi CM, Chandra P, Santeford A, Menos AM, Dong Z, Wang ER, Qian W, Karozichian ES, Philips JA , Apte RS. HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon . Cell Reports. 2020 Nov 3;33(5):108339. doi: 10.1016/j.celrep.2020.108339
Chandra P, He L, Zimmerman M, Yang G, Köster S, Ouimet M, Wang H, Moore KJ, Dartois V, Schilling JD, Philips JA . Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis. mBio. 2020 Jul 7;11(4). doi: 10.1128/mBio.01139-20. PubMed PMID: 32636249; PubMed Central PMCID: PMC7343992.
Watsa M, Erkenswick G, Prost S, Davis EO, Moore C, Kubiski S, Witte C, Ogden R, Meredith A, Ryder OA, Steiner CC, Philips JA , Owen MA. Rigorous wildlife disease surveillance . Science. 2020 July 09; 369(6500):145-147.
Mittal E, Skowyra ML, Uwase G, Tinaztepe E, Mehra A, Köster S, Hanson PI,Philips JA. Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response. MBio . 2018 Nov 27;9(6). pii: e01765-18. doi: 10.1128/mBio.01765-18. PMID: 30482832
Upadhyay S, Mittal E, Philips JA . Tuberculosis and the art of macrophage manipulation. Pathog Dis . 2018 Jun 1;76(4). doi: 10.1093/femspd/fty037. PMID: 29762680
Köster S, Upadhyay S, Philips JA. Why macrophages cannot LAP up TB. A utophagy . 2018 Jan 9:1-5. doi: 10.1080/15548627.2018.1425054. [Epub ahead of print] PMID:29313424
Chandra P, Philips JA . Ectopic Gene Expression in Macrophages Using in vitro Transcribed mRNA. Bio-protocol . 2018; 10:e2857. doi: 10.21769/BioProtoc.2857.
Köster S, Klevorn T, Papavinasasundaram K, Sassetti C, Portal-Celhay C, Philips, JA . Consequences of enhanced LC3-trafficking for a live, attenuated M. tuberculosis vaccine. Vaccine , https://doi.org/10.1016/j.vaccine.2018.01.012
Köster S, Upadhyay S, Chandra P, Papavinasasundaram K, Yang G, Hassan A, Grigsby S, Mittal E, Park HS, Jones V, Hsu F, Jackson M, Sassetti C, Philips, JA . Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. Proc. Natl. Acad. Sci ., 2017: pii:20107792. doi: 10.1073/pnas.1707792114 (Epub ahead of print).
Portal-Celhay C, Tufariello JM, Srivastava S, Mehra A, Zahra A, Bean AJ, Ernst JD, Jacobs Jr. WR*, Philips JA.* Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent MHC class II antigen presentation, Nature Microbiol 2016: 2, 16232. (*equal contribution)
Featured in Neyrolles, O. Bacterial Pathogenesis: A sand grain in antigen processing. Nature Microbiol 2016: 2, 16234. PMID: 27918496
See Behind The Paper , Portal-Celhay C. The route towards T cell activation: how TB and I crossed paths: https://naturemicrobiologycommunity.nature.com/users/24403-cynthia-portal-celhay/posts/13820-the-route-towards-t-cell-activation-how-tb-and-i-crossed-paths
Tinaztepe E, Wei J-R, Raynowska J, Portal-Celhay C, Thompson V, and Philips, JA. The role of metal dependent regulation of ESX-3 secretion on the intracellular survival of Mycobacterium tuberculosis . Infect Immun 2016; May 31, pii: IAI00197-16 [Epub ahead of print]; PMID:27245412.
Ouimet M, Koster S, Sakowski, E, Ramkhelawon B, Van Solingen C, Oldebeken S, Karunakaran D, Portal-Celhay C, Sheedy FJ, Ray TD, Cecchini K, Zamore PD, Rayner KJ, Marcel YL, Philips JA ,* Moore KJ.* Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism,Nat Immunol 2016; 17 , 677-686. PMCID: PMC4873392. (*equal contribution)
Tufariello JM, Chapman JR, Kerantzas CA, Wong KW, Vilchèze C, Jones CM, Cole LE, Tinaztepe E, Thompson V, Fenyö D, Niederweis M, Ueberheide B, Philips JA *, Jacobs WR Jr*. Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence. Proc Natl Acad Sci U S A . 2016 Jan 19;113(3):E348-57; (*equal contribution)
Sakowski E, Koster S, Portal Celhay C, Park HS, Shrestha E, Hetzenecker SE, Maurer K, Cadwell K, Philips JA . Ubiquilin 1 Promotes IFN-gamma-induced xenophagy of Mycobacterium tuberculosis . PLOS Pathogens . 2015 Jul 30;11(7):e1005076.
Vaeth M, Zee I, Concepcion AR, Maus M, Shaw P, Portal-Celhay C, Zahra A, Kozhaya L, Weidinger C, Philips J, Unutmaz D, Feske S. Ca2+ Signaling but Not Store-Operated Ca2+ Entry is Required for the Function of Macrophages and Dendritic Cells. J Immunol. , 2015 Aug 1;195(3):1202-17. Epub 2015 Jun 24.
Mehra A*, Zahra A*, Thompson V, Sirisaengtaksin N, Wells A, Porto M, Koster, S, Penberthy K, Kubota Y, Dricot A, Rogan D, Vidal M, Hill DE, Bean AJ, Philips JA . Mycobacterium tuberculosis Type VII secreted effector EsxH targets host ESCRT to impair trafficking. PLOS Pathogens . 2013 Oct;9(10):e1003734. PMID 24204276; * equal contribution. doi: 10.1371/journal.ppat.1003734 .
Cadwell, K Philips, JA . Autophagy meets phagocytosis. Immunity. 2013 Sept 19;39(3): 425-427. PMID: 24054324. doi: 10.1016/j.immuni.2013.08.027 .
Philips, JA Ernst JD. Tuberculosis and Immunity. Annu. Rev. Pathol. 2012 7: 353-384. PMID: 22054143. doi: 10.1146/annurev-pathol-011811-132458.
Philips JA , Ernst JD. Directly observing therapy: a new view of drug tolerance in tuberculosis. Cell . 2011 Apr 1;145(1):13-4. PMID 21458661. doi: 10.1016/j.cell.2011.02.041 .
Philips JA . Mycobacterial manipulation of vacuolar sorting. Cell Microbiol . 2008 Dec;10(12):2408-15. PMID 18783482. doi: 10.1111/j.1462-5822.2008.01239.x .
Philips JA , Porto MC, Wang H, Rubin EJ, Perrimon N. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A . 2008 Feb 26;105(8):3070-5. PMID 18287038. doi: 10.1073/pnas.0707206105 .
Philips JA , Marty FM, Stone RM, Koplan BA, Katz JT, Baden LR. Torsades de pointes associated with voriconazole use. Transpl Infect Dis . 2007 Mar;9(1):33-6. PMID 17313469. doi: 10.1111/j.1399-3062.2006.00160.x .
Philips JA , Rubin EJ, Perrimon N. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science . 2005 Aug 19;309(5738):1251-3. PMID 16020694. doi: 10.1126/science.1116006 .
Agaisse H, Burrack LS, Philips JA , Rubin EJ, Perrimon N, Higgins DE. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science . 2005 Aug 19;309(5738):1248-51. PMID 16020693. doi: 10.1126/science.1116008 .