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Seth A, Mittal E, Luan J, Kolla S, Mazer MB, Joshi H, Gupta R, Rathi P, Wang Z, Morrissey JJ, Ernst JD, Portal-Celhay C, Morley SC, Philips JA, Singamaneni S. High-resolution imaging of protein secretion at the single-cell level using plasmon-enhanced FluoroDOT assay. Cell Rep Methods. 2022 Aug 22;2(8):100267. doi: 10.1016/j.crmeth.2022.100267. eCollection 2022 Aug 22. PubMed PMID: 36046626; PubMed Central PMCID: PMC9421537. Chandra P, Grigsby SJ, Philips JA. Immune evasion and provocation by Mycobacterium tuberculosis. Nat Rev Microbiol. 2022 Jul 25;. doi: 10.1038/s41579-022-00763-4. [Epub ahead of print] Review. PubMed PMID: 35879556; PubMed Central PMCID: PMC9310001. Chandra P, Coullon H, Agarwal M, Goss CW, Philips JA. Macrophage global metabolomics identifies cholestenone as host/pathogen cometabolite present in human Mycobacterium tuberculosis infection. J Clin Invest. 2022 Feb 1;132(3). doi: 10.1172/JCI152509. PubMed PMID: 35104812; PubMed Central PMCID: PMC8803325.
Inomata M, Xu S, Chandra P, Meydani SN, Takemura G, Philips JA, Leong JM. Macrophage LC3-associated phagocytosis is an immune defense against Streptococcus pneumoniae that diminishes with host aging. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33561-33569. doi: 10.1073/pnas.2015368117. Epub 2020 Dec 21. PubMed PMID: 33376222; PubMed Central PMCID: PMC7776987. Miner JJ, Platt DJ, Ghaznavi CM, Chandra P, Santeford A, Menos AM, Dong Z, Wang ER, Qian W, Karozichian ES, Philips JA , Apte RS. HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon . Cell Reports. 2020 Nov 3;33(5):108339. doi: 10.1016/j.celrep.2020.108339 Chandra P, He L, Zimmerman M, Yang G, Köster S, Ouimet M, Wang H, Moore KJ, Dartois V, Schilling JD, Philips JA . Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis. mBio. 2020 Jul 7;11(4). doi: 10.1128/mBio.01139-20. PubMed PMID: 32636249; PubMed Central PMCID: PMC7343992. Watsa M, Erkenswick G, Prost S, Davis EO, Moore C, Kubiski S, Witte C, Ogden R, Meredith A, Ryder OA, Steiner CC, Philips JA , Owen MA. Rigorous wildlife disease surveillance . Science. 2020 July 09; 369(6500):145-147.
Mittal E, Skowyra ML, Uwase G, Tinaztepe E, Mehra A, Köster S, Hanson PI,Philips JA. Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response. MBio . 2018 Nov 27;9(6). pii: e01765-18. doi: 10.1128/mBio.01765-18. PMID: 30482832 Upadhyay S, Mittal E, Philips JA . Tuberculosis and the art of macrophage manipulation. Pathog Dis . 2018 Jun 1;76(4). doi: 10.1093/femspd/fty037. PMID: 29762680 Köster S, Upadhyay S, Philips JA. Why macrophages cannot LAP up TB. A utophagy Chandra P, Philips JA . Ectopic Gene Expression in Macrophages Using in vitro Transcribed mRNA. Bio-protocol . 2018; 10:e2857. doi: 10.21769/BioProtoc.2857. Köster S, Klevorn T, Papavinasasundaram K, Sassetti C, Portal-Celhay C, Philips, JA . Consequences of enhanced LC3-trafficking for a live, attenuated M. tuberculosis vaccine. Vaccine , https://doi.org/10.1016/j.vaccine.2018.01.012
Köster S, Upadhyay S, Chandra P, Papavinasasundaram K, Yang G, Hassan A, Grigsby S, Mittal E, Park HS, Jones V, Hsu F, Jackson M, Sassetti C, Philips, JA . Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. Proc. Natl. Acad. Sci ., 2017: pii:20107792. doi: 10.1073/pnas.1707792114 (Epub ahead of print).
Portal-Celhay C, Tufariello JM, Srivastava S, Mehra A, Zahra A, Bean AJ, Ernst JD, Jacobs Jr. WR*, Philips JA.* Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent MHC class II antigen presentation, Nature Microbiol 2016: 2, 16232. Featured in Neyrolles, O. Bacterial Pathogenesis: A sand grain in antigen processing. Nature Microbiol 2016: 2, 16234. PMID: 27918496 See Behind The Paper , Portal-Celhay C. The route towards T cell activation: how TB and I crossed paths: https://naturemicrobiologycommunity.nature.com/users/24403-cynthia-portal-celhay/posts/13820-the-route-towards-t-cell-activation-how-tb-and-i-crossed-paths Tinaztepe E, Wei J-R, Raynowska J, Portal-Celhay C, Thompson V, and Philips, JA. The role of metal dependent regulation of ESX-3 secretion on the intracellular survival of Mycobacterium tuberculosis . Infect Immun 2016; May 31, pii: IAI00197-16 [Epub ahead of print]; PMID:27245412. Ouimet M, Koster S, Sakowski, E, Ramkhelawon B, Van Solingen C, Oldebeken S, Karunakaran D, Portal-Celhay C, Sheedy FJ, Ray TD, Cecchini K, Zamore PD, Rayner KJ, Marcel YL, Philips JA ,* Moore KJ.* Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism,Nat Immunol 2016; 17 , 677-686. PMCID: PMC4873392. (*equal contribution) Tufariello JM, Chapman JR, Kerantzas CA, Wong KW, Vilchèze C, Jones CM, Cole LE, Tinaztepe E, Thompson V, Fenyö D, Niederweis M, Ueberheide B, Philips JA *, Jacobs WR Jr*. Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence. Proc Natl Acad Sci U S A . 2016 Jan 19;113(3):E348-57; (*equal contribution)
Sakowski E, Koster S, Portal Celhay C, Park HS, Shrestha E, Hetzenecker SE, Maurer K, Cadwell K, Philips JA . Ubiquilin 1 Promotes IFN-gamma-induced xenophagy of Mycobacterium tuberculosis . PLOS Pathogens Vaeth M, Zee I, Concepcion AR, Maus M, Shaw P, Portal-Celhay C, Zahra A, Kozhaya L, Weidinger C, Philips J, Unutmaz D, Feske S. Ca2+ Signaling but Not Store-Operated Ca2+ Entry is Required for the Function of Macrophages and Dendritic Cells. J Immunol. , 2015 Aug 1;195(3):1202-17. Epub 2015 Jun 24.
Mehra A*, Zahra A*, Thompson V, Sirisaengtaksin N, Wells A, Porto M, Koster, S, Penberthy K, Kubota Y, Dricot A, Rogan D, Vidal M, Hill DE, Bean AJ, Philips JA . Mycobacterium tuberculosis Type VII secreted effector EsxH targets host ESCRT to impair trafficking. PLOS Pathogens . 2013 Oct;9(10):e1003734. PMID 24204276; * equal contribution. doi: 10.1371/journal.ppat.1003734 . Cadwell, K Philips, JA . Autophagy meets phagocytosis. Immunity. 2013 Sept 19;39(3): 425-427. PMID: 24054324. doi: 10.1016/j.immuni.2013.08.027 .
Philips, JA Ernst JD. Tuberculosis and Immunity. Annu. Rev. Pathol. 2012 7: 353-384. PMID: 22054143. doi: 10.1146/annurev-pathol-011811-132458. Philips JA , Ernst JD. Directly observing therapy: a new view of drug tolerance in tuberculosis. Cell . 2011 Apr 1;145(1):13-4. PMID 21458661. doi: 10.1016/j.cell.2011.02.041 .Philips JA . Mycobacterial manipulation of vacuolar sorting. Cell Microbiol . 2008 Dec;10(12):2408-15. PMID 18783482. doi: 10.1111/j.1462-5822.2008.01239.x .Philips JA , Porto MC, Wang H, Rubin EJ, Perrimon N. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A . 2008 Feb 26;105(8):3070-5. PMID 18287038. doi: 10.1073/pnas.0707206105 .Philips JA , Marty FM, Stone RM, Koplan BA, Katz JT, Baden LR. Torsades de pointes associated with voriconazole use. Transpl Infect Dis . 2007 Mar;9(1):33-6. PMID 17313469. doi: 10.1111/j.1399-3062.2006.00160.x .Philips JA , Rubin EJ, Perrimon N. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science . 2005 Aug 19;309(5738):1251-3. PMID 16020694. doi: 10.1126/science.1116006 .Agaisse H, Burrack LS, Philips JA , Rubin EJ, Perrimon N, Higgins DE. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science . 2005 Aug 19;309(5738):1248-51. PMID 16020693. doi: 10.1126/science.1116008 .